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The Delaware Division of Public Health (DPH) continues to investigate reports of SARS in Delaware, but none have met the clinical and epidemiologic case definition. This Update provides information about:
Questions about this update can be directed to DPH at 1-888-295-5156.
Clinical specimens for patients meeting the case definition below should be submitted to the Delaware DPH laboratory. DPH is preparing to conduct both EIA for detection of antibody in serum and PCR for molecular detection of virus in clinical specimens. These tests should be available by mid-June. The DPH Laboratory can also coordinate submission of specimens for laboratory analysis by CDC. Contact the DPH Laboratory for further information at (302) 653-2870 about specimen collection and consent forms, and related procedures.
The previous CDC SARS case definition (published May 23, 2003) has been updated. The last date for illness onset for persons who meet the clinical criteria for SARS and who report travel to Singapore have been revised. The “last date of illness onset” for Singapore (Table) is now June 14, 2003.
|Area||1st date of illness on set for inclusion as reported case‡||Last date of illness onset for inclusion as reported case†|
|China (mainland)||November 1, 2002||Ongoing|
|Hong Kong||February 1, 2003||Ongoing|
|Hanoi, Vietnam||February 1, 2003||May 25, 2003|
|Singapore||February 1, 2003||June 14, 2003|
|Toronto, Canada||April 23, 2003||Ongoing|
|Taiwan||May 1, 2003||Ongoing|
A case may be excluded as a suspect or probable SARS case if:
* A measured documented temperature of >100.4º F (>38º C) is preferred. However, clinical judgment should be used when evaluating patients for whom a measured temperature of >100.4º F (>38º C) has not been documented. Factors that might be considered include patient self-report of fever, use of antipyretics, presence of immunocompromising conditions or therapies, lack of access to health care, or inability to obtain a measured temperature. Reporting authorities should consider these factors when classifying patients who do not strictly meet the clinical criteria for this case definition.
§ Close contact is defined as having cared for or lived with a person known to have SARS or having a high likelihood of direct contact with respiratory secretions and/or body fluids of a patient known to have SARS. Examples of close contact include kissing or embracing, sharing eating or drinking utensils, close conversation (<3 feet), physical examination, and any other direct physical contact between persons. Close contact does not include activities such as walking by a person or sitting across a waiting room or office for a brief period of time.
‡ The WHO has specified that the surveillance period for China should begin on November 1; the first recognized cases in Hong Kong, Singapore and Hanoi (Vietnam) had onset in February 2003. The dates for Toronto and Taiwan are linked to CDC’s issuance of travel recommendations.
† The last date for illness onset is 10 days (i.e., one incubation period) after removal of a CDC travel alert. The case patient’s travel should have occurred on or before the last date the travel alert was in place.
¶ Assays for the laboratory diagnosis of SARS-CoV infection include enzyme-linked immunosorbent assay, indirect fluorescent-antibody assay, and reverse transcription polymerase chain reaction (RT-PCR) assays of appropriately collected clinical specimens (Source: CDC. Guidelines for collection of specimens from potential cases of SARS. Available at : http://www.cdc.gov/ncidod/sars/specimen_collection_sars2.htm ). Absence of SARS-CoV antibody from serum obtained <21 days after illness onset, a negative PCR test, or a negative viral culture does not exclude coronavirus infection and is not considered a definitive laboratory result. In these instances, a convalescent serum specimen obtained >21 days after illness is needed to determine infection with SARS-CoV. All SARS diagnostic assays are under evaluation.
** Asymptomatic SARS-CoV infection or clinical manifestations other than respiratory illness might be identified as more is learned about SARS-CoV infection.
*** Factors that may be considered in assigning alternate diagnoses include the strength of the epidemiologic exposure criteria for SARS, the specificity of the diagnostic test, and the compatibility of the clinical presentation and course of illness for the alternative diagnosis.