Frequently Asked Questions SYPHILIS What is SYPHILIS? Syphilis is a complex sexually transmitted disease (STD) caused by the bacterium Treponema pallidum. It is often called "the great imitator" because many of its signs and symptoms resemble those of other diseases. How do people Syphilis is passed from person to person through direct contact get syphilis? with a syphilis sore, or ulcer. Sores occur mainly on the external genitals, vagina, anus, or in the rectum. Sores also can occur on the lips and in the mouth which means that it can also be spread by kissing someone with a sore in their mouth or on their lips. Transmission of the organism occurs during vaginal, anal or oral sex. What are the signs and There are four stages of syphilis: primary, secondary, latent symptoms of syphilis and tertiary. in adults? Primary Stage The primary stage of syphilis is usually marked by the appearance of a single sore (called a chancre), but there may be multiple sores. The chancre is usually firm, round, small, and painless. If adequate treatment is not administered, the infection progresses to the secondary stage. Secondary Stage The second stage starts when one or more areas of the skin break into a rash that usually does not itch. The rash often appears as rough, red or reddish brown spots both on the palms of the hands and on the bottoms of the feet. In addition to rashes, second-stage symptoms can include fever, swollen lymph glands, sore throat, patchy hair loss, headaches, weight loss, muscle aches, and tiredness. Latent Stage The latent (hidden) stage of syphilis begins when the secondary symptoms disappear. Without treatment, the infected person still has syphilis even though there are no signs or symptoms. It remains in the body, and it may begin to damage the internal organs, including the brain, nerves, eyes, heart, blood vessels, liver, bones and joints. This internal damage may show up many years later in the late or tertiary stage of syphilis. Tertiary Stage Late stage signs and symptoms include not being able to coordinate muscle movements, paralysis, numbness, gradual blindness and dementia. This damage may be serious enough to cause death. Can a newborn Yes. Depending on how long a pregnant woman has been get syphilis? infected, she has a good chance of having a stillbirth (syphilitic stillbirth) or of giving birth to a baby who dies shortly after birth. If not treated immediately, an infected baby may be born without symptoms but could develop them within a few weeks. These signs and symptoms can be very serious. Untreated babies may become developmentally delayed, have seizures, die. How is syphilis There are laboratory tests to diagnose syphilis. Shortly after diagnosed? infection occurs, the body produces syphilis antibodies that can be detected by a blood test. A low level of antibodies will stay in the blood for months or years even after the disease was successfully treated. How is syphilis treated? Syphilis is easy to cure in its early stages. A single intramuscular injection of penicillin, an antibiotic, will cure a person who has had syphilis for less than a year. Additional doses are needed to treat someone who has had syphilis for longer than a year. Will syphilis recur? Having syphilis once does not protect a person from getting it again. Following successful treatment, people can still be susceptible to re-infection. How can syphilis The surest way to avoid transmission of sexually transmitted be prevented? diseases, including syphilis, is to abstain from sexual contact or to be in a long-term monogamous relationship with a partner who was tested and is known to be uninfected. Correct and consistent use of latex or polyurethane condoms can reduce the risk of syphilis only when the infected area or site of potential exposure (the sore) is protected. For more information: Call the Centers for Disease Control and Prevention at 1-800-232-4636, TTY: 1-888-232-6348 In English en Espaņol. Contact Number: STD Program, (302) 744-1050 Revised: 03/2007 Doc. # 35-05-20/07/03/15